Modified Release

Optimize your modified-release formulations

Expert support for your modified-release programs

Modified-release formulations are designed to deliver a drug over a defined period of time and/or to a particular region of the body. By doing this, drug delivery can be optimized to balance therapeutic need, manage adverse event (AE) profiles, and reduce dosing frequency, which contribute to improved patient compliance.

The demand for modified-release formulations is driven by many factors related to both patient and therapeutic needs. For most conditions, patients generally demand either once-daily or twice-daily treatments, requiring sustained drug concentrations throughout the treatment period.

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Although modified-release formulations can offer many therapeutic benefits for both drug developers and patients, there are several challenges to overcome when trying to develop this type of formulation. With over three decades of expertise, Quotient Sciences has designed modified-release formulations in gastro-retention, sustained-release, pulsatile-release and other formats.

We can help you with with even the most challenging modified-release programs. Access our latest info sheet to find out how our modified-release formulation strategies and technologies can help your molecule achieve clinical and commercial success.

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More information about modified-release formats

Modified-release format	Objective	Formulation technology
Gastro-retention	Keep the formulation in the stomach for an extended period to maximize the duration of absorption or therapeutic activity	Swellable tablets (monolithic, bilayer, trilayer)
Gastro-resistant	Prevent release of the drug in the stomach and/or upper gastrointestinal (GI) tract Overcome first-pass metabolism or gastric irritation	Enteric-coated tablets or capsules
Sustained or extended release	Extend the in-vivo release profile of the drug or enable once-daily dosing	Matrix tablets, coated tablets, or multiparticulates
Targeted or controlled delivery	Release the drug at or near the intended site of absorption or action Have either immediate-release or extended-release characteristics Deliver time-, pH-, or microbially-triggered release	Tablets, capsules, or multiparticulates
Biphasic release	Eliminate the need for repeat dosing Provide rapid therapeutic effect from an immediate-release layer and extended dosing from a sustained-release layer	Bilayer tablets or multiparticulates
Pulsatile release	Release the drug as a pulse after a pre-determined lag time, designed according to the body’s circadian rhythm Provide a release mechanism beneficial for drugs where time-dependent dosing is required or those that undergo first-pass metabolism	Bilayer tablets or multiparticulates

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