Modified Release

Optimize your modified-release formulations

The demand for modified-release formulations is driven by many factors related to both patient and therapeutic needs. For most conditions, patients generally demand either once-daily or twice-daily treatments, requiring sustained drug concentrations throughout the treatment period.

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Modified-release formulations are designed to deliver your drug over a defined period of time and/or to a particular region of the body. By doing this, drug delivery can be optimized to balance therapeutic need, manage adverse event (AE) profiles, and reduce dosing frequency, which contribute to improved patient compliance.

Quotient Sciences has extensive experience in designing modified-release formulations, from gastro-retention to sustained-release and pulsatile-release formats. Learn more about how we can help tailor your programs in our latest info sheet.

Modified-release format Objective Formulation technology
  • Keep the formulation in the stomach for an extended period to maximize the duration of absorption or therapeutic activity
Swellable tablets (monolithic, bilayer, trilayer)
  • Prevent release of the drug in the stomach and/or upper gastrointestinal (GI) tract
  • Overcome first-pass metabolism or gastric irritation
Enteric-coated tablets or capsules
Sustained or extended release
  • Extend the in-vivo release profile of the drug or enable once-daily dosing
Matrix tablets, coated tablets, or multiparticulates
Targeted or controlled delivery
  • Release the drug at or near the intended site of absorption or action
  • Have either immediate-release or extended-release characteristics
  • Deliver time-, pH-, or microbially-triggered release
Tablets, capsules, or multiparticulates
Biphasic release
  • Eliminate the need for repeat dosing
  • Provide rapid therapeutic effect from an immediate-release layer and extended dosing from a sustained-release layer
Bilayer tablets or multiparticulates
Pulsatile release
  • Release the drug as a pulse after a pre-determined lag time, designed according to the body’s circadian rhythm
  • Provide a release mechanism beneficial for drugs where time-dependent dosing is required or those that undergo first-pass metabolism
Bilayer tablets or multiparticulates

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Expert support for your modified-release programs

Although modified-release formulations can offer many therapeutic benefits for both drug developers and patients, there are several challenges to overcome when trying to develop this type of formulation. With over 30 years of expertise, Quotient Sciences can help with even the most challenging modified-release programs.

Access our latest info sheet to find out how our modified-release formulation strategies and technologies can help your molecule achieve clinical and commercial success.

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