The demand for modified release formulations is driven by many factors related to both patient and therapeutic need. For most conditions, patients generally demand either once or twice daily treatments requiring sustained drug concentrations throughout the treatment period. Modified release formulations are designed to deliver your drug over a defined period of time and/or to a particular region of the body. By doing this, drug delivery can be optimized to balance therapeutic need, manage AE profiles and reduce dosing frequency, which contribute to improved patient compliance.
Quotient Sciences has extensive experience in designing modified release formulations, from gastro-retention to sustained and pulsatile release formats as outlined below.
Modified release format | Objective | Formulation technology |
Gastro-retention |
|
Swellable tablets (monolithic, bilayer, trilayer) |
Gastric bypass |
|
Enteric coated tablets or capsules |
Sustained or extended release |
|
Matrix tablets, coated tablets or multiparticulates |
Targeted or controlled delivery |
|
Tablets, capsules or multiparticulates |
Biphasic release |
|
Bilayer tablets or multiparticulates |
Pulsatile release |
|
Bilayer tablets or multiparticulates |