Bioanalysis

Over 40 years of experience delivering rapid bioanalytical data in discovery, preclinical and clinical development stages.

Rapid bioanalytical data to meet your program's milestones

At a Glance

 

Our GLP- and GCP-accredited facilities provide comprehensive bioanalytical support to studies through preclinical, through to Phase I, and onwards to Phase II and III.

We deliver rapid bioanalytical data in the discovery, preclinical, and clinical stages. Our state-of-the-art equipment includes: LC-MS/MS, LC-HR-MS, ICP-MS, ICP-MS/MS, GC-MS, and GC-MS/MS.

We are experts in the development, validation, and application of bioanalytical assays with over 40 years of scientific expertise.

For our customers, we have developed over 400 methods (LC-MS, GC-MS, ICP-MS). We have expertise in specialist areas including; Insulin analogues & polypeptide drugs, elemental analysis, volatile drugs, and biomarkers.

We offer expert TK and PK data analysis and reporting, supporting pre-clinical and clinical studies. Working together with our expert PK team, we can reduce the risk of downstream delays in later phases of your drug development.

Our experts can quickly develop, validate, and implement bioanalytical LC-MS, GC-MS, and ICP-MS assays for small- and large-molecule drugs, biomarkers, and elements in compliance with regulatory standards.

Broad range of platforms

  • Liquid chromatography with mass spectrometry (LC-MS)
  • Inductively coupled plasma mass spectrometry (ICP-MS)
  • Gas chromatography with mass spectrometry (GC-MS)

High-resolution mass spectrometry

  • Liquid chromatography with ion-trap mass spectrometry (LC-TRAP-MS)
  • Liquid chromatography with time-of-flight mass spectrometry (LC-TOF-MS)

Global compliance and regulatory

  • Good Laboratory Practice (GLP)- and Good Clinical Practice (GCP)-accredited laboratories
  • US Food and Drug Administration (FDA)
  • European Medicines Agency (EMA)
  • UK Medicines and Healthcare products Regulatory Agency (MHRA)

Specialist areas of expertise

  • Insulin analogues and polypeptide drugs
  • Elemental analysis
  • Volatile drugs and biomarkers

Comprehensive bioanalytical support at every stage

A closer look at our equipment and applications

InstrumentationApplications
  • Inductively coupled plasma mass spectrometry (ICP-MS)
  • Inductively coupled plasma tandem mass spectrometry (ICP-MS/MS)
  • Elemental analysis
  • Xevo ultra-performance liquid chromatography with tandem mass spectrometry (UPLC-MS/MS)
  • Analysis of small-molecule new chemical entities (NCEs)
  • Analysis of peptides, small proteins, and new biological entities (NBEs)
  • Highly sensitive, with a lower limit of quantification (LLOQ) <1 ng/mL
  • High throughput
  • Quantum and Vantage UPLC-MS/MS
  • Analysis of small-molecule NCEs
  • Sensitive, with a LLOQ ~1 ng/mL
  • High throughput
  • Gas chromatography with mass spectrometry (GC-MS)
  • Gas chromatography with tandem mass spectrometry (GC-MS/MS)
  • Detection and analysis of volatile analytes for NCEs and biomarkers
  • Liquid chromatography with quadrupole time-of-flight mass spectrometry (LC-QTOF-MS)
  • High-resolution structural identification for NCEs
  • Peptide and protein identification
  • NBE analysis
  • Liquid chromatography with inductively coupled plasma tandem mass spectrometry (LC-ICP-MS/MS)
  • Elemental speciation
  • Liquid chromatography with ion-trap mass spectrometry (LC-TRAP-MS)
  • High-resolution structural identification for NCEs
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