As we start 2021 with renewed hope in how medical science will deliver global healthcare benefits, I would like to share an update on the scientific activities at Quotient Sciences during the last 12 months.
We take great pride in the science and innovation that we help bring to drug development, and the way we work with our customers to design and deliver integrated programs of work that accelerate their medicines to patients. We believe it’s important to publish research findings from these collaboration programs of work and hence I’m pleased to share that in 2020 Quotient presented 10 scientific posters at global conferences and had five peer-reviewed articles published in scientific journals. We are grateful to our customers for their support, and to our talented scientists involved in the research projects. We are firm believers that sharing knowledge with the wider pharma community will help accelerate the development of new medicines around the world; therefore details and links to some of the key papers and posters are provided below.
As we ‘look to the horizon’, we strive to anticipate and address future customer and market needs. Throughout 2020, we continued to invest in new drug product manufacturing and analytical technologies across our global site network, including particle size reduction, amorphous solid dispersions, and solid-state characterization. Working with customers we also developed new technologies to optimize oral drug delivery, including gastroretentive systems and zero-order release formulations. Our multiple research collaborations with leading Universities also continued, which is helping us translate research into industrial practice. A recent example is the deployment of 3D printing technology for tablet production in our laboratories.
Please contact us if you would like any further information
Scientific Posters
"A Quality by Design Approach to Optimize and Accelerate Formulation and Process Development Leading towards Registration Batches Manufacturing"
AAPS PharmSci 360
"Development of High Drug Load Multiparticulate Beads Using an Extrusion-Spheronization Process"
AAPS PharmSci 360
"Addressing the scale-up challenge of a Low-Dose Tablet Formulation through blending and roller compaction optimization"
AAPS PharmSci 360
"Improving the Stability of a Spray-Dried Peroxide-Susceptible Drug in Tablets"
AAPS PharmSci 360
"Development of Radiolabeled Surrogate Beads for Tracing Gastrointestinal Transit of Oral Multiparticulate Formulations"
AAPS PharmSci 360
"Flexible formulation assessments in FIH studies for poorly soluble drugs accelerates dosage form development, manufacturing and supply for patient POC trials"
AAPS PharmSci 360
"Development of an X-Ray Diffraction Method for the Quantification of API Recrystallized From Amorphous API in A Low Dose Dry Powder For Inhalation Formulation"
RDD conference
"A Clinical Assessment of Delayed-Release Coated Capsule Compositions for Regional Gastrointestinal Delivery using Gamma Scintigraphy"
CRS (Controlled Release Society) Meeting and Exposition
"Risk-Based Monitoring from a Phase I Clinical Site Perspective"
Society of Quality Assurance Annual Meeting
"Current practice in the conduct of acceptability/palatability/swallowability trials:
A review of methodology associated with trials registered on the EU clinical trials portfolio"
European Paediatric Formulation Initiative (EuPFI)
Scientific Papers
"Phase I evaluation of the safety, tolerability, and pharmacokinetics of GSK3640254, a next-generation HIV-1 maturation inhibitor.”
British Pharmacological Society Journal
"Can children swallow tablets? Outcome data from a feasibility study to assess the acceptability of different-sized placebo tablets in children"
BMJ peer-reviewed journal
"Development of AITC‐induced dermal blood flow as a translational in vivo biomarker of TRPA1 activity in human and rodent skin"
British Pharmacological Society Journal
"Best Practices in the Development and Validation of Physiologically Based Biopharmaceutics Modeling. A Workshop Summary Report"
Journal of Pharmaceutical Sciences