Drug Substance Development & Manufacturing

Tailored drug substance services to suit your needs. Learn about our drug substance synthesis and manufacturing capabilities.

Reduce drug substance manufacturing costs by 50% from preclinical to Phase I.

The First Kilograms of GMP Drug Substance

Learn more about our capabilities in our latest whitepaper.

At a Glance


We always strive to produce economical processes for high-purity drug substances that can be rapidly scaled from grams to multi-kilograms. Our highly experienced chemistry, analytical, and drug development teams can support route selection, process development, critical process parameter (CPP) definition, experimental design (DoE), and impurity tracking/control, as well as developing bespoke and innovative solutions for our customers' technically difficult challenges.

We adopt a streamlined approach to developing drug substances at our state-of-the-art facility in Alnwick, UK. This has been shown to reduce manufacturing costs by 50% from pre-clinical to Phase I.

At our facility in Alnwick, UK we have made some significant investments in equipment and technologies to meet the increasing demand for complex small-scale drug substance manufacturing.

We pride ourselves on quickly delivering high-purity drug substances and can rapidly scale up manufacturing at our cutting-edge facility. With more than 40 years of experience in synthetic organic chemistry, coupled with extensive expertise in flow chemistry, synthetic biology, and biocatalysis, we can optimize manufacturing processes and save months of development time for our customers.

A multi-million-pound state-of-the-art building expansion of our Alnwick, UK, facility delivers comprehensive, integrated support for customers bridging from candidate selection to early clinical development and beyond. The newly expanded space features multi-purpose capacity of up to 15 GMP reactor streams with reactor volumes ranging from 5 liters up to 150 liters and deployment of both batch or continuous flow chemistry technologies.

Creating the foundation for successful API development

Dr. Gareth Jenkins
Drug Substance, Gareth Jenkins

Innovative Trends in Continuous Drug Substance Manufacturing: The FlowInova Platform

By: Dr. Gareth Jenkins Download Whitepaper

Drug Substance API: What our customers say

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