AAPS PharmSci360 2022

16 October 2022 - 19 October 2022

Join us for AAPS 2022!

Quotient Sciences drug development experts will be at the AAPS PharmSci360 event in Boston, MA in October. Join us at booth #419 to discuss your drug development needs and be sure to watch presentations featuring Dr. Shriram Pathak, Senior Research Fellow, during the event.

To schedule a meeting with our team at the event, fill out the form below.

Highlights for AAPS 2022

Presentation on Monday, October 17 | Starting 10am ET 

Dr. Shriram Pathak, Senior Research Fellow, will present Model Informed Drug Development: A Key Metric to Expedite Compound Progression in Drug Discovery, during the morning symposium: Bridging The Cross-Functional Silos To Expedite Compound Progression Into The Clinic (CE).

Presentation Overview

Introduction of PBPK modeling early in the programme can help maximize the utilization of drug’s early physchem, in-vitro and pre-clinical dataset to inform downstream decision-making. For instance, at candidate selection stages, M&S can provide valuable insights about the key drug attributes viz. selection of an appropriate solid state (amorphous vs crystalline polymorph); requirement of particle size reduction; possible food effect; membrane permeation; blood binding and tissue distribution parameters etc. allowing for maximum leverage from the limited dataset available and thereby ensuring program is well prepared for entering the clinical phase. Modeling techniques can also help understanding the drivers of reduced oral bioavailability of early drug candidates and can inform downstream formulation decision-making so that the efforts can be focused on the correct techniques to provide meaningful improvements in in-vivo performance, and at the same time, avoiding the risk of jumping to overly complex formulations which may add an unnecessary time and cost to the drug development process. This session will introduce the current state of knowledge and present real time case studies demonstrating how an optimum use of PBPK modeling techniques can support a ‘rationale’ drug development, thereby expediting the process of moving potential lead candidates from discovery to the clinic and subsequent commercialization.

Learning Objectives

  • Present the value and purpose of key in-silico (viz. PBPK) modeling techniques in early drug development programmes.
  • Introduce the current state of knowledge and highlight how PBPK modeling can be used to risk assess lead compounds prior entering the clinical phase.
  • Discuss the current knowledge gaps and critical challenges within the field and help exchanging of ideas to move this fundamental science further.
Poster presentations on Monday, October 17

From 10:30am-11:30am ET
Kilo Scale Synthesis in Daisy Chained Flow Rectors (M130-08-47)
Presenting author: Felicity Roberts, Flow Chemist

From 12:30pm-1:30pm ET
Formulation and Taste Assessments in First in Human Studies–Evolving beyond Safety, Tolerability, and Pharmacokinetics (M1230-11-62)
Presenting author: Dr. Vanessa Zann, Sr. Drug Development Consultant

Apologies our event is sold out!- Complimentary Lunch Seminar with Charles River on Tuesday, October 18

From 11:30am-1:30pm ET
Join experts from Charles River & Quotient Sciences for a complimentary lunch seminar from 11:30am-1:00pm at Morton’s Steakhouse, entitled: 'Integrated Strategies for Accelerating from Discovery to IND and Beyond: Charles River & Quotient Sciences Collaboration'

Happy Hour Networking Reception on Tuesday, October 18

From 5:00pm-7:00pm ET
Mix and mingle with scientific colleagues and our drug substance and drug development experts at Legal Harborside on Tuesday, Oct 18th from 5:00pm to 7:00pm.  
For more information or to sign up click here.

Presentation at Simulation Plus Forum on Tuesday, October 18

From 6:00pm-9:00pm
Dr Shriram Pathak, will be giving a talk entitled:"Leveraging PBPK modeling to accelerate drug product development" at the 18th Annual Simulation Plus Forum taking place at the Westin Boston Seaport hotel, in the Douglas Room.
Click here to RSVP

Panel discussion on Wednesday, October 19 | Starting 3pm ET

Dr. Shriram Pathak, Senior Research Fellow, will co-moderate the discussion, Hot Topic: Classification Systems in Formulation Development Strategies, along with Professor James E. Polli, Ph.D., FAAPS from the University of Maryland School of Pharmacy.