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Strategies for Accelerating the Development of Modified Release Oral Forms

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Case Studies


Protein kinase inhibitors (PKIs) are used in the treatment of cancer and inflammation, but food interactions are a common problem with this class of drugs. Swedish drug delivery company Xspray has used its Hybrid Nanoparticle (HyNap™) technology to improve the bioavailability of the PKI nilotinib, reducing the required dose and significantly lowering the food interaction of the drug compared with the marketed product. Dr Andreas Konar at Xspray, explained how Quotient’s Translational Pharmaceutics® platform helped to accelerate one of their development programs, to overcome insolubility challenges with protein kinase inhibitors.

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