On-Demand: Improve Drug Solubility from Formulation to Scale-Up

In this presentation we explore approaches including hot melt extrusion, spray-dried dispersions, lipid-based formulations and particle size reduction, while highlighting how early formulation decisions can reduce downstream development and manufacturing risks.

Quotient Sciences' speakers Robert Cornog, Senior Director, Product Development, and Dr. Andrew Parker, Executive Drug Development Consultant, discuss how a connected development strategy can help address drug solubility challenges from formulation selection through scale-up. They are joined by Dr. Mark A. Krook, CMC & Early Drug Development at NGT Biopharma Consultants.

Key learning objectives: 

• How to assess poorly soluble molecules and develop a fit-for-purpose formulation strategy aligned with clinical objectives
• Key considerations for selecting between HME, spray drying, lipid-based and particle size reduction approaches
• ASD Science and challenges for developing stable ASDs
• How to reduce scale-up and technology transfer risks through early formulation and manufacturing planning
• The value of integrating formulation development, manufacturing and clinical testing to accelerate decision-making and development timelines

Watch our on-demand recording and stay at the forefront of treatment advancements in this quickly evolving category.