Candidate Development
Selecting the right molecules for development
Knowing what it takes to develop a successful drug, we help clients select the best molecules for development.
Our unique integration of scientific capabilities enables us to provide a complete assessment of molecule “developability”. Through this, we quickly identify the best drug candidates – the potential winners – mitigating risks for our clients and shortening the time to reach the clinic.
Resources
Read our related case studies
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Info SheetDrug Substance Synthesis and ManufacturingTactical deployment of best-in-class synthesis technologies to minimize chemistry costs and move your drug substance supply off the critical path.
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Case StudiesDCS classification of NCE - Case studyUS Biotech wanted to determine the DCS (Developability Classification System) designation for their small molecule. This included project scope and outcomes of the project.
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Scientific PostersAAPS 2019 Poster- Comparison of Two In-Silico Modeling Programs, ADMET Predictor® and Percepta® to Predict Intrinsic Solubility and pKa of Poorly Soluble DrugsPresented at AAPS 2019: Aqueous solubility is a prerequisite for oral absorption of a drug and the pH-dependence of aqueous solubility is critical information to guide formulation development strategies. The purpose of this study was to evaluate the physical property modules in two commercially available in-silico modelling programs in predicting the pH solubility profiles as described by the ionization constant (pKa) and the intrinsic solubility of the unionized form.
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Case StudiesEndevica Case Study - Peptide Program using Translational PharmaceuticsEndevica Bio is developing TCMCB07 as a novel synthetic peptide product for the potential treatment of cachexia. Read how they leveraged the Quotient Sciences Translational Pharmaceutics platform for this program.
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