Modified release

How do I optimize my modified release formulation? Quotient is your answer.

The demand for modified release formulations is driven by many factors related to both patient and therapeutic need. For most conditions, patients generally demand either once or twice daily treatments requiring sustained drug concentrations throughout the treatment period. Modified release formulations are designed to deliver your drug over a defined period of time and/or to a particular region of the body. By doing this, drug delivery can be optimized to balance therapeutic need, manage AE profiles and reduce dosing frequency, which contribute to improved patient compliance.

Quotient Sciences has extensive experience in designing modified release formulations, from gastro-retention to sustained and pulsatile release formats as outlined below.

Modified release format Objective Formulation technology
  • Keep the formulation in the stomach for an extended period to maximize the duration of absorption or therapeutic activity.
Swellable tablets (monolithic, bilayer, trilayer)
Gastric bypass
  • Prevent release of the drug in the stomach and/or upper gastrointestinal tract.
  • Overcome first-pass metabolism or gastric irritation.
Enteric coated tablets or capsules
Sustained or extended release
  • Extend the in vivo release profile of the drug or enable once daily dosing.
Matrix tablets, coated tablets or multiparticulates
Targeted or controlled delivery
  • Release the drug at or near the intended site of absorption or action.
  • Have either immediate or extended release characteristics.
  • Deliver time, pH or microbially-triggered release.
Tablets, capsules or multiparticulates
Biphasic release
  • Eliminate the need for repeat dosing.
  • Provide rapid therapeutic effect from an immediate release layer and extended dosing via a sustained release layer.
Bilayer tablets or multiparticulates
Pulsatile release
  • Release the drug as a pulse after a predetermined lag time — designed according to the body’s circadian rhythm.
  • Provide release mechanism beneficial for drugs where time-dependent dosing is required or those that undergo first-pass metabolism.
Bilayer tablets or multiparticulates
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