Overcoming poor drug solubility and bioavailability challenges with the use of pharmaceutical spray drying

We use a broad range of formulation approaches to address complex solubility and bioavailability challenges, ensuring technology selection is driven by molecule need. Learn more about our services for pharmaceutical spray drying and how it can benefit your poorly soluble small molecule.

An overview of Quotient Sciences Spray Dried Dispersions Services

Drug solubility has a significant impact on bioavailability. 70% of new chemical entities (NCEs) suffer from low aqueous solubility that can result in failure during clinical testing due to poor bioavailability. Selecting an appropriate drug formulation is imperative to the success of the program. 

At Quotient Sciences we use a broad range of formulation approaches to address complex solubility and bioavailability challenges, ensuring technology selection is driven by molecule need. Within our technology portfolio, spray drying is an established capability. Our experts tailor formulation strategies based on the unique physical, chemical and biopharmaceutics properties of each drug, working within state-of-the-art facilities capable of handling high potent compounds.

Our Translational Pharmaceutics approach enables First-in-Human studies by re-engineering the transition of your drug molecule into clinical development and shortening the timeline to Proof-of-Concept.

Quotient Sciences have the expertise to overcome the challenges that arise with handling highly potent API (HPAPI). Download our info sheet to learn more.

Expertise to meet the challenges of pediatric drug development.

Quotient Sciences' expertise and capabilities in pediatric formulation development, combined with our global drug product manufacturing and clinical testing capabilities, enable us to meet the complex technical challenges of pediatric products and provide you with a unique integrated development solution. 

We work to customize a pharmaceutical development program for your pediatric product across its development life cycle to include preformulation studies, formulation development, analytical characterization and dosing simulation, product stability, scale-up process development, clinical trial supplies, PK/taste assessment and optimization, regulatory support, and commercial drug product production.

Partner with us to design and deliver your clinical pharmacology program.

Quotient Sciences is dedicated to Phase I trials and early drug development, helping you accelerate your molecule from first-in-human (FIH) trials to proof of concept (POC). We focus on providing the insights you need by offering comprehensive clinical pharmacology services for all Phase I study programs. 

Our services encompass expert clinical study design, thorough data analysis, and detailed reporting. With our fully integrated approach, we ensure seamless execution and deliver high-quality results safely and quickly.

We work with you to develop the most appropriate drug product formulation to meet your phase of development.

Our innovative approach to drug product formulation development is based on our proven track record in early clinical evaluation, delivering phase-appropriate formulations across the product development pathway from preclinical to late-stage. 

With expertise in formulation development to meet the needs of both simple and complex dosage forms, our approach has been validated through our work with over 1,500 molecules at all stages of development.

How our formulation development services can help

Contact us today to learn how we can help:

• Identify and address critical formulation issues quickly
• Optimize the performance of your drug product formulation for further clinical testing and scale-up
• Support your drug product formulation at all stages, from preclinical onward

We provide full service support for small molecule non-sterile programs, from dosage formulation development through to GMP clinical trial manufacturing and commercial drug product supply.

Achieve your goals by integrating on-demand drug product manufacturing with clinical testing. 

Quotient Sciences Translational Pharmaceutics® is our unique platform which accelerates drug development, trusted for more than 17 years. Global pharmaceutical and biotech companies have successfully used Translational Pharmaceutics® since 2008. Learn more about how it works.

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Quotient Sciences is a recognized leader in applying physiologically based pharmacokinetic (PBPK) modeling and simulation (M&S) science, as well as physiologically based biopharmaceutical modeling (PBBM), to accelerate drug development.

We leverage advanced modelling platforms— GastroPlus™, PK-Sim^®, and MoBi^®—selecting the most appropriate tool for each project. Our team provides expert guidance on predicting the potential in vivo performance of drugs and formulations, helping to shape product design and clinical development strategies.

With nearly 30 years of experience, Quotient has established a broad suite of technologies and formulation approaches to address these complex solubility challenges. Our approach allows us to dramatically speed up the optimization of your drug products to improve oral bioavailability.