Article
Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial
Synucleinopathies such as Parkinsońs disease (PD), Dementia with Lewy odies (DLB) and Multiple System Atrophy (MSA) are characterized by deposition of misfolded and aggregated a-synuclein. Small aggregates
(oligomers) of a-synuclein have been shown to be the most relevant neurotoxic species and are targeted by anle138b, an orally bioavailable small molecule compound which shows strong disease-modifying effects in animal models of synucleinopathies.