Co-administering clofazimine with infant formula enhances its oral bioavailability in rats and pigs

This study involving Vanessa Zann (VP of Scientific Consulting) at Quotient Sciences, investigates the feasibility of using commercially available infant formula as an enabling formulation to enhance the solubilization and oral bioavailability of clofazimine, a poorly soluble lipophilic drug.

The solubilization of crystalline clofazimine in digesting infant formula was assessed in vitro using synchrotron small-angle X-ray scattering. An in vivo pharmacokinetic study was then conducted to determine the oral bioavailability of a suspension of clofazimine in infant formula compared to a lipid-free aqueous suspension in both a rat and piglet animal model.