Qualification of Gastroplus® PBPK modelling software to support decision-making in clinical development

Quotient Sciences uses GastroPlus® PBPK modeling software to support clinical development decision-making

Quotient Sciences’ modeling & simulation team presented a scientific poster at PKUK 2022, detailing the qualification of GastroPlus® PBPK modeling software. The project aimed to validate the software’s predictive performance across diverse drug types, formulations, and clinical scenarios.

Using a repository of case studies, the team compared simulated pharmacokinetic outcomes with observed clinical data to assess model accuracy and precision. The results confirmed that GastroPlus® software can reliably predict real-world outcomes, making it a qualified platform for physiologically based pharmacokinetic modeling in drug development.

With modeling & simulation tools like GastroPlus® software, Quotient Sciences can offer data-driven formulation strategies that reduce development risk and support regulatory submissions.