Isotope Labelling
Secure & rapid delivery of isotopically labelled (14C/SIL) materials for non-clinical & clinical human studies.
With over 30 years of successful delivery on-site, Quotient Sciences' highly trained chemists have extensive chemical and radiochemical knowledge and the experience required to supply consultancy and advice on the most suitable labelling positions for a variety of molecular entities.
Isotope Labelling Services Include:
•GMP & non GMP synthesis
•14C radiolabelling
•Ability to handle highly potent/high hazard compounds (cytotoxics)
•Synthesis of metabolites & reference standards aiding bioanalytical and metabolism studies
•Degradants and process impurities to support API development
•Route development and precursor synthesis for labelling with 3H and short-lived isotopes 11C and 18F
•Classical and non-classical synthetic techniques
•Flow chemistry
•Automated peptide synthesis capability
•Microbiological and bio-catalysis
•Stable isotope label (SIL) synthesis, including 2H, 13C, 15N & 18O
Isotope Labelling Resources
-
Info SheetIsotope LabellingWhether you need isotopically labelled (14C/SIL) compounds for nonclinical or clinical metabolism studies and the quantification of materials in biological matrices, our expertise provides the necessary labelled materials tailored to support your studies.
-
Case StudiesStable Isotope Labelling Case StudyMultiple, biotechnology and large-pharma companies needing isotope labelling support for their ADME/hAME studies
-
WhitepaperThe First Kilograms of GMP Drug SubstanceAt Quotient Sciences, a core component of our integrated offering is our capability in drug substance process research, development, and manufacturing, carried out at our state-of-the-art facility in Alnwick, UK. Read our latest white paper on our drug substance capabilities.
-
ArticleConference Report from the European Bioanalysis Forum Workshop: toward harmonized implementation of the ICH M10 guidelineIn this report, the European Bioanalysis Forum shares the proposals for harmonized implementation of the ICH M10 guideline on bioanalytical method validation and study sample analysis from the ICH M10 workshop.
Ready to get started?
Connect With Quotient Today