Modified-Release Formulation Strategies
Overview
CRDMO services that enable modified-release dosage forms
Quotient Sciences capabilities for modified-release span the entire development pathway, from candidate development through to commercialization, reducing development risks and simplifying the supply chain for our customers.
Taking an integrated CRDMO approach tailored to each program, we provide optimal results for our customers in the most efficient and cost-effective manner.
Solubility-driven formulation design: Exploring modified-release formats and modified-release technologies
| What modified-release format is used? | What is the objective of this modified-release format? | What modified-release formulation technology is available? |
|---|---|---|
| Gastro-retention | A gastro-retention formulation stays in the stomach for an extended period to maximize the duration of absorption or therapeutic activity. | Swellable tablets (monolithic, bilayer, trilayer) |
| Gastro-resistant | A gastro-resistant formulation prevents release of the drug in the stomach and/or upper gastrointestinal (GI) tract, to overcome first-pass metabolism or gastric irritation. | Enteric-coated tablets or capsules |
| Sustained or extended release | A sustained or extended release format extends the in-vivo release profile of the drug or enable once-daily dosing. | Matrix tablets, coated tablets, or multiparticulates |
| Targeted or controlled delivery | A targeted or controlled delivery format releases the drug at or near the intended site of absorption or action, with either immediate-release or extended-release characteristics. They can also deliver time-, pH-, or microbially-triggered release. | Tablets, capsules, or multiparticulates |
| Biphasic release | A biphasic release delivery format eliminates the need for repeat dosing, giving rapid therapeutic effect from an immediate-release layer and extended dosing from a sustained-release layer. | Bilayer tablets or multiparticulates |
| Pulsatile release | A pulsatile release format releases the drug after a pre-determined lag time, as a pulse designed according to the body’s circadian rhythm. This release mechanism is beneficial for drugs that undergo first-pass metabolism or where time-dependent dosing is required. | Bilayer tablets or multiparticulates |
