Scientific Publications

Published, original scientific articles written by our experts, reviewed by peers.

Human ADME, Clinical Pharmacology

Astrazeneca - A Phase 1 Study to Evaluate Absolute Bioavailability and Absorption, Distribution, Metabolism and Excretion of Savolitinib in Healthy Male Volunteers

6 June 2023 Read More

Download our Peer Reviewed Publications

Peer Reviewed Publication, Human ADME, Clinical Pharmacology

Astrazeneca - A Phase 1 Study to Evaluate Absolute Bioavailability and Absorption, Distribution, Metabolism and Excretion of Savolitinib in Healthy Male Volunteers

6 June 2023

Download Now

Peer Reviewed Publication, Formulation Development, Human ADME, First-in-Human

Astrazeneca - Mass balance recovery and disposition of AZD4831 in humans

13 January 2023

Download Now

Peer Reviewed Publication, Pediatrics, Drug Substance, Drug Product

Practical and operational considerations related to paediatric oral drug formulation: An industry survey

14 December 2022

Download Now

Peer Reviewed Publication, Pediatrics, Drug Product, Drug Substance

Practical and operational considerations related to pediatric oral drug formulation: An industry survey

14 December 2022

Download Now

Peer Reviewed Publication, Materials Science

Controlled synthesis of SPION@SiO2 nanoparticles using design of experiments

13 December 2022

Download Now

Peer Reviewed Publication, Clinical Pharmacology

CC-99677, A Novel, Oral, Selective Covalent MK2 Inhibitor, Sustainably Reduces Pro-inflammatory Cytokine Production

23 August 2022

Download Now

Peer Reviewed Publication, Clinical Pharmacology

CC-99677: A Novel, Oral, Selective Covalent MK2 Inhibitor, Sustainably Reduces Pro-inflammatory Cytokine Production

23 August 2022

Download Now

Peer Reviewed Publication, Human ADME

ADME of opicapone in human healthy volunteers

16 June 2022

Download Now

Peer Reviewed Publication, Translational Pharmaceutics, Clinical Pharmacology, First-in-Human

Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial

3 May 2022

Download Now

Peer Reviewed Publication, Drug Product Optimization

Absolute Bioavailability, Mass Balance, and Metabolic Profiling Assessment of [14C]-Belumosudil in Healthy Men: A Phase 1, Open-Label, 2-Part Study

15 March 2022

Download Now

Peer Reviewed Publication, Drug Product Optimization

A Phase 1 Pharmacokinetic Drug Interaction Study of Belumosudil Coadministered With CYP3A4 Inhibitors and Inducers and Proton Pump Inhibitors

15 March 2022

Download Now

Peer Reviewed Publication, Drug Product Optimization

Phase 1 Studies to Evaluate the Food Effect and Relative Bioavailability of Tablet and Capsule Formulations of Belumosudil in Healthy Adult Subjects

15 March 2022

Download Now

Peer Reviewed Publication, Drug Product Optimization

ACCP: A Phase 1 Pharmacokinetic Drug Interaction Study of Belumosudil Coadministered With CYP3A4 Inhibitors and Inducers and Proton Pump Inhibitors

7 March 2022

Download Now

Peer Reviewed Publication, Materials Science

Controlled synthesis of SPION@SiO2 nanoparticles using design of experiments

13 February 2022

Download Now

Peer Reviewed Publication, Human ADME, Clinical Pharmacology, First-in-Human

Astrazeneca - Characterization of Clinical ADME & Pharmacokinetics of Velsecorat Using an IV Microtracer Combined with an Inhaled Dose in Healthy Subjects

2 February 2022

Download Now

Peer Reviewed Publication, Modified Release, Formulation Development

Development of a Once‑Daily Modified‑Release Formulation for the Short Half‑Life RIPK1 Inhibitor GSK2982772 using DiffCORE Technology

10 January 2022

Download Now

Peer Reviewed Publication, Clinical Pharmacology

Effect of Miricorilant, a Selective Glucocorticoid Receptor Modulator, on Olanzapine-Associated Weight Gain in Healthy Subjects

3 January 2022

Download Now

Peer Reviewed Publication, Clinical Pharmacology, First-in-Human

Dose Finding and Food Effect Studies of a Novel Abiraterone Acetate Formulation for Oral Suspension in Comparison to a Reference Formulation in Healthy Male Subjects

16 December 2021

Download Now

Peer Reviewed Publication, Human ADME, First-in-Human

Scientific Paper_Pharmacokinetics and Metabolism of Ziritaxestat (GLPG1690) in Healthy Male Volunteers Following Intravenous and Oral Administration

1 September 2021

Download Now

Peer Reviewed Publication, Formulation Development, Oral Peptides

Development and approval of rybelsus (oral semaglutide): ushering in a new era in peptide delivery

1 May 2021

Download Now

Peer Reviewed Publication, Bioanalysis

Scientific Paper_Inductively coupled plasma mass spectrometry method for plasma and intracellular antimony quantification applied to pharmacokinetics of meglumine antimoniate

1 May 2021

Download Now

Peer Reviewed Publication, Modified Release

Scientific Paper_ Development of a Prototype, Once-Daily, Modified Release Formulation for the Short Half-Life RIPK1 Inhibitor GSK2982772

1 February 2021

Download Now

Peer Reviewed Publication, Clinical Pharmacology

A phase 1/1b study of PUR1900, an inhaled formulation of itraconazole, in healthy volunteers and asthmatics to study safety, tolerability and pharmacokinetics

23 January 2020

Download Now

Peer Reviewed Publication, Clinical Pharmacology

2019 Jones et al - Absence of pharmacokinetic interactions between the Bruton's Tyrosine Kinase Inhibitor Fenebrutinib and Methotrexate ~Gen

21 January 2020

Download Now

Peer Reviewed Publication, Translational Pharmaceutics, Formulation Development, Clinical Pharmacology

Application of a Novel ‘Make and Test in Parallel’ Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects

23 November 2018

Download Now

Learn more about Quotient Sciences' services

See how we can help you with your next drug program.

Humanity can't afford to wait, so neither can we.

Let's talk

Scientific Publications

Astrazeneca - A Phase 1 Study to Evaluate Absolute Bioavailability and Absorption, Distribution, Metabolism and Excretion of Savolitinib in Healthy Male Volunteers

Download our Peer Reviewed Publications

Astrazeneca - A Phase 1 Study to Evaluate Absolute Bioavailability and Absorption, Distribution, Metabolism and Excretion of Savolitinib in Healthy Male Volunteers

Astrazeneca - Mass balance recovery and disposition of AZD4831 in humans

Practical and operational considerations related to paediatric oral drug formulation: An industry survey

Practical and operational considerations related to pediatric oral drug formulation: An industry survey

Controlled synthesis of SPION@SiO2 nanoparticles using design of experiments

CC-99677, A Novel, Oral, Selective Covalent MK2 Inhibitor, Sustainably Reduces Pro-inflammatory Cytokine Production

CC-99677: A Novel, Oral, Selective Covalent MK2 Inhibitor, Sustainably Reduces Pro-inflammatory Cytokine Production

ADME of opicapone in human healthy volunteers

Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial

Absolute Bioavailability, Mass Balance, and Metabolic Profiling Assessment of [14C]-Belumosudil in Healthy Men: A Phase 1, Open-Label, 2-Part Study

A Phase 1 Pharmacokinetic Drug Interaction Study of Belumosudil Coadministered With CYP3A4 Inhibitors and Inducers and Proton Pump Inhibitors

Phase 1 Studies to Evaluate the Food Effect and Relative Bioavailability of Tablet and Capsule Formulations of Belumosudil in Healthy Adult Subjects

ACCP: A Phase 1 Pharmacokinetic Drug Interaction Study of Belumosudil Coadministered With CYP3A4 Inhibitors and Inducers and Proton Pump Inhibitors

Controlled synthesis of SPION@SiO2 nanoparticles using design of experiments

Astrazeneca - Characterization of Clinical ADME & Pharmacokinetics of Velsecorat Using an IV Microtracer Combined with an Inhaled Dose in Healthy Subjects

Development of a Once‑Daily Modified‑Release Formulation for the Short Half‑Life RIPK1 Inhibitor GSK2982772 using DiffCORE Technology

Effect of Miricorilant, a Selective Glucocorticoid Receptor Modulator, on Olanzapine-Associated Weight Gain in Healthy Subjects

Dose Finding and Food Effect Studies of a Novel Abiraterone Acetate Formulation for Oral Suspension in Comparison to a Reference Formulation in Healthy Male Subjects

Scientific Paper_Pharmacokinetics and Metabolism of Ziritaxestat (GLPG1690) in Healthy Male Volunteers Following Intravenous and Oral Administration

Development and approval of rybelsus (oral semaglutide): ushering in a new era in peptide delivery

Scientific Paper_Inductively coupled plasma mass spectrometry method for plasma and intracellular antimony quantification applied to pharmacokinetics of meglumine antimoniate

Scientific Paper_ Development of a Prototype, Once-Daily, Modified Release Formulation for the Short Half-Life RIPK1 Inhibitor GSK2982772

A phase 1/1b study of PUR1900, an inhaled formulation of itraconazole, in healthy volunteers and asthmatics to study safety, tolerability and pharmacokinetics

2019 Jones et al - Absence of pharmacokinetic interactions between the Bruton's Tyrosine Kinase Inhibitor Fenebrutinib and Methotrexate ~Gen

Application of a Novel ‘Make and Test in Parallel’ Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects

Drug Substance Synthesis & Manufacturing

Translational Pharmaceutics®

Clinical Pharmacology

Drug Product Development & Manufacturing