Scientific Publications

Published, original scientific articles written by our experts, reviewed by peers.

Human ADME, Clinical Pharmacology

Astrazeneca - A Phase 1 Study to Evaluate Absolute Bioavailability and Absorption, Distribution, Metabolism and Excretion of Savolitinib in Healthy Male Volunteers

6 June 2023 Read More

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Peer Reviewed Publication, Clinical Pharmacology, Translational Pharmaceutics

Placebo-controlled First-in-Human Study of Oral TQS-168 in Healthy Volunteers

17 December 2024

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Peer Reviewed Publication, Clinical Pharmacology

In Vitro and Clinical Evaluations of UGT1A1-, P-gp-, OATP1B1-, and BCRP-Mediated Drug–Drug Interactions of Belumosudil, a Potent ROCK2 Inhibitor

17 December 2024

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Peer Reviewed Publication, Human ADME, Clinical Pharmacology

Astrazeneca - A Phase 1 Study to Evaluate Absolute Bioavailability and Absorption, Distribution, Metabolism and Excretion of Savolitinib in Healthy Male Volunteers

6 June 2023

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Peer Reviewed Publication, Formulation Development, Human ADME, First-in-Human

Astrazeneca - Mass balance recovery and disposition of AZD4831 in humans

13 January 2023

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Peer Reviewed Publication, Pediatrics, Drug Product, Drug Substance

Practical and operational considerations related to pediatric oral drug formulation: An industry survey

14 December 2022

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Peer Reviewed Publication, Materials Science

Controlled synthesis of SPION@SiO2 nanoparticles using design of experiments

13 December 2022

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Peer Reviewed Publication, Clinical Pharmacology

CC-99677: A Novel, Oral, Selective Covalent MK2 Inhibitor, Sustainably Reduces Pro-inflammatory Cytokine Production

23 August 2022

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Peer Reviewed Publication, Clinical Pharmacology

CC-99677, A Novel, Oral, Selective Covalent MK2 Inhibitor, Sustainably Reduces Pro-inflammatory Cytokine Production

23 August 2022

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Peer Reviewed Publication, Human ADME

ADME of opicapone in human healthy volunteers

16 June 2022

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Peer Reviewed Publication, Translational Pharmaceutics, Clinical Pharmacology, First-in-Human

Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial

3 May 2022

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Peer Reviewed Publication, Drug Product Optimization

A Phase 1 Pharmacokinetic Drug Interaction Study of Belumosudil Coadministered With CYP3A4 Inhibitors and Inducers and Proton Pump Inhibitors

15 March 2022

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Peer Reviewed Publication, Drug Product Optimization

Absolute Bioavailability, Mass Balance, and Metabolic Profiling Assessment of [14C]-Belumosudil in Healthy Men: A Phase 1, Open-Label, 2-Part Study

15 March 2022

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Peer Reviewed Publication, Drug Product Optimization

ACCP: A Phase 1 Pharmacokinetic Drug Interaction Study of Belumosudil Coadministered With CYP3A4 Inhibitors and Inducers and Proton Pump Inhibitors

7 March 2022

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Peer Reviewed Publication, Human ADME, Clinical Pharmacology, First-in-Human

Astrazeneca - Characterization of Clinical ADME & Pharmacokinetics of Velsecorat Using an IV Microtracer Combined with an Inhaled Dose in Healthy Subjects

2 February 2022

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Peer Reviewed Publication, Modified Release, Formulation Development

Development of a Once‑Daily Modified‑Release Formulation for the Short Half‑Life RIPK1 Inhibitor GSK2982772 using DiffCORE Technology

10 January 2022

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Peer Reviewed Publication, Clinical Pharmacology

Effect of Miricorilant, a Selective Glucocorticoid Receptor Modulator, on Olanzapine-Associated Weight Gain in Healthy Subjects

3 January 2022

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Peer Reviewed Publication, Clinical Pharmacology, First-in-Human

Dose Finding and Food Effect Studies of a Novel Abiraterone Acetate Formulation for Oral Suspension in Comparison to a Reference Formulation in Healthy Male Subjects

16 December 2021

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Peer Reviewed Publication, Human ADME, First-in-Human

Scientific Paper_Pharmacokinetics and Metabolism of Ziritaxestat (GLPG1690) in Healthy Male Volunteers Following Intravenous and Oral Administration

1 September 2021

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Peer Reviewed Publication, Formulation Development, Oral Peptides

Development and approval of rybelsus (oral semaglutide): ushering in a new era in peptide delivery

1 May 2021

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Peer Reviewed Publication, Bioanalysis

Scientific Paper_Inductively coupled plasma mass spectrometry method for plasma and intracellular antimony quantification applied to pharmacokinetics of meglumine antimoniate

1 May 2021

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Peer Reviewed Publication, Modified Release

Scientific Paper_ Development of a Prototype, Once-Daily, Modified Release Formulation for the Short Half-Life RIPK1 Inhibitor GSK2982772

1 February 2021

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Peer Reviewed Publication, Clinical Pharmacology

A phase 1/1b study of PUR1900, an inhaled formulation of itraconazole, in healthy volunteers and asthmatics to study safety, tolerability and pharmacokinetics

23 January 2020

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Peer Reviewed Publication, Clinical Pharmacology

2019 Jones et al - Absence of pharmacokinetic interactions between the Bruton's Tyrosine Kinase Inhibitor Fenebrutinib and Methotrexate ~Gen

21 January 2020

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Peer Reviewed Publication, Translational Pharmaceutics, Formulation Development, Clinical Pharmacology

Application of a Novel ‘Make and Test in Parallel’ Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects

23 November 2018

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Scientific Publications

Astrazeneca - A Phase 1 Study to Evaluate Absolute Bioavailability and Absorption, Distribution, Metabolism and Excretion of Savolitinib in Healthy Male Volunteers

Download our Peer Reviewed Publications

Placebo-controlled First-in-Human Study of Oral TQS-168 in Healthy Volunteers

In Vitro and Clinical Evaluations of UGT1A1-, P-gp-, OATP1B1-, and BCRP-Mediated Drug–Drug Interactions of Belumosudil, a Potent ROCK2 Inhibitor

Astrazeneca - A Phase 1 Study to Evaluate Absolute Bioavailability and Absorption, Distribution, Metabolism and Excretion of Savolitinib in Healthy Male Volunteers

Astrazeneca - Mass balance recovery and disposition of AZD4831 in humans

Practical and operational considerations related to pediatric oral drug formulation: An industry survey

Controlled synthesis of SPION@SiO2 nanoparticles using design of experiments

CC-99677: A Novel, Oral, Selective Covalent MK2 Inhibitor, Sustainably Reduces Pro-inflammatory Cytokine Production

CC-99677, A Novel, Oral, Selective Covalent MK2 Inhibitor, Sustainably Reduces Pro-inflammatory Cytokine Production

ADME of opicapone in human healthy volunteers

Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial

A Phase 1 Pharmacokinetic Drug Interaction Study of Belumosudil Coadministered With CYP3A4 Inhibitors and Inducers and Proton Pump Inhibitors

Absolute Bioavailability, Mass Balance, and Metabolic Profiling Assessment of [14C]-Belumosudil in Healthy Men: A Phase 1, Open-Label, 2-Part Study

ACCP: A Phase 1 Pharmacokinetic Drug Interaction Study of Belumosudil Coadministered With CYP3A4 Inhibitors and Inducers and Proton Pump Inhibitors

Astrazeneca - Characterization of Clinical ADME & Pharmacokinetics of Velsecorat Using an IV Microtracer Combined with an Inhaled Dose in Healthy Subjects

Development of a Once‑Daily Modified‑Release Formulation for the Short Half‑Life RIPK1 Inhibitor GSK2982772 using DiffCORE Technology

Effect of Miricorilant, a Selective Glucocorticoid Receptor Modulator, on Olanzapine-Associated Weight Gain in Healthy Subjects

Dose Finding and Food Effect Studies of a Novel Abiraterone Acetate Formulation for Oral Suspension in Comparison to a Reference Formulation in Healthy Male Subjects

Scientific Paper_Pharmacokinetics and Metabolism of Ziritaxestat (GLPG1690) in Healthy Male Volunteers Following Intravenous and Oral Administration

Development and approval of rybelsus (oral semaglutide): ushering in a new era in peptide delivery

Scientific Paper_Inductively coupled plasma mass spectrometry method for plasma and intracellular antimony quantification applied to pharmacokinetics of meglumine antimoniate

Scientific Paper_ Development of a Prototype, Once-Daily, Modified Release Formulation for the Short Half-Life RIPK1 Inhibitor GSK2982772

A phase 1/1b study of PUR1900, an inhaled formulation of itraconazole, in healthy volunteers and asthmatics to study safety, tolerability and pharmacokinetics

2019 Jones et al - Absence of pharmacokinetic interactions between the Bruton's Tyrosine Kinase Inhibitor Fenebrutinib and Methotrexate ~Gen

Application of a Novel ‘Make and Test in Parallel’ Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects

Drug Substance Synthesis & Manufacturing

Translational Pharmaceutics® Integrated Drug Development

Clinical Pharmacology

Drug Product Development & Manufacturing