Scientific Posters
Our scientific developments and breakthroughs.
Honolulu Acoziborole Radiosynthesis, Human ADME
Mass Balance Recovery, Absorption, Metabolism, and Excretion of [14C]Acoziborole in Healthy Male Subjects after Single Microtracer Oral Dosing I – Preparation of GMP [14C]Acoziborole Drug Substance
8 October 2024 Read MoreDownload our Scientific Posters
Scientific Poster,
Formulation Development
Use of ASAPprime in a Pharmaceutical CMDO space
24 April 2025
Scientific Poster,
Solubility Enhancement
Unleashing Bioavailability: Particle Size, Salt Form, and the Race Against Disproportionation
9 April 2025
Scientific Poster,
Modelling & Simulation, Sodium Salcaprozate SNAC, Oral Peptides, Peptide Drug Development, Pharmacokinetics
Physiologically Based Biopharmaceutics Modelling of the Effect of a Permeability Enhancer on the Absorption of a Highly Soluble and Poorly Permeable Small Peptide in Humans
6 November 2024
Scientific Poster,
Belumosudil , Drug-drug interactions, CYP3A4 inhibitor itraconazole
Quotient Sciences Predicting Belumosudil Drug-Drug Interactions Using a Physiologically Based Pharmacokinetic Model
6 November 2024
Scientific Poster,
Salcaprozate sodium SNAC, Reduced PBPK Model, Paracellular Permeability
Modelling and Simulation of the Effect of a Permeability Enhancer on the Absorption of a Poorly Permeable Compound
6 November 2024
Scientific Poster,
Honolulu Acoziborole Metabolism, Human ADME
Investigation of the Matabolite Profile of Acoziborole in Plasma Urine and Fecal Homogenate Samples Using UPLC-MS Fractionation Followed by AMS Analysis
8 October 2024
Scientific Poster,
Honolulu Acoziborole Clinical and Mass Balance, Human ADME
A Single Dose Study to Assess the Mass Balance Recovery, Absorption, Metabolism, and Excretion of [14C]-Acoziborole in Healthy Male Subjects After Oral Dosing
8 October 2024
Scientific Poster,
Honolulu Acoziborole Radiosynthesis, Human ADME
Mass Balance Recovery, Absorption, Metabolism, and Excretion of [14C]Acoziborole in Healthy Male Subjects after Single Microtracer Oral Dosing I – Preparation of GMP [14C]Acoziborole Drug Substance
8 October 2024
Scientific Poster,
Human ADME, First-in-Human
Practical Impact of the FDA Draft Guidance on Human Mass Balance Studies - A year of Client Discussions
6 December 2023
Scientific Poster,
Modified Release, sci
ASCP 2023: A Phase 1 SAD and MAD Trial of EVX-101, a Novel Gastro-Retentive Prolonged Release
9 October 2023
Scientific Poster,
Pediatrics
EuPFI: Taste Assessment Study of Tenapanor Pediatric Solution Formulations
25 September 2023
Scientific Poster,
Translational Pharmaceutics
CRS 2023: Development of a Multi-Pill Abuse Resistant (MPAR®) Multiparticulate Modified Release Formulation to Prevent Opioid Overdose
14 August 2023
Scientific Poster,
Commercial Manufacturing, Clinical Trial Manufacturing, Solubility Enhancement
The use of electrospraying as a means of drug loading into mesoporous silica particles for enhanced dissolution
5 January 2023
Scientific Poster,
Iain Shaw, Human ADME, Clinical Pharmacology
ISSX 2022: A Decade of Human ADME at Quotient Sciences: Reviewing Key Study Design Variables and Outcomes
14 December 2022
Scientific Poster,
Pediatrics, Clinical Trial Manufacturing
Safety, tolerability, and pharmacokinetics of the oligomer modulator anle138b: a first-in-human randomized, double-blind, placebo-controlled Phase 1 trial
14 December 2022
Scientific Poster,
Pediatrics, Clinical Pharmacology
Understanding the Absorption, Metabolism and Excretion of Masitinib in Healthy Male Subjects
14 December 2022
Scientific Poster,
Pediatrics, Clinical Pharmacology, Modelling & Simulation
ACoP 2022 Poster: Benznidazole pharmacokinetics in adults and children: Application of PBPK modelling
13 December 2022
Scientific Poster,
Oncology, Clinical Pharmacology
ESMO Immuno-Oncology Poster: Hubro Therapeutics QSC204718 (Vaccine Study)
13 December 2022
Scientific Poster,
Pediatrics, Formulation Development
Development of a novel oral suspension formulation of a candidate API for administration to pediatric patients
13 December 2022
Scientific Poster,
Clinical Pharmacology, Modelling & Simulation
Qualification of Gastroplus® PBPK modelling software to support decision-making in clinical development
13 December 2022
Scientific Poster,
Drug Substance, Formulation Development
AAPS 2022 Poster: Kilo Scale Synthesis in Daisy Chained Flow Reactors
3 November 2022
Scientific Poster,
First-in-Human, Formulation Development
AAPS 2022 Poster: Formulation and Taste Assessments in First in Human Studies
3 November 2022
Scientific Poster,
First-in-Human
BPS 2022 Poster: A Phase 1 Randomized PK Study of Amilo-5MER
22 September 2022
Scientific Poster,
Clinical Pharmacology, First-in-Human
A Phase 1, Randomized, Double-Blind, Placebo Controlled, First-in-Human Study to Assess Safety, Tolerability & Pharmacokinetics (PK) of Amilo-5MER in Healthy Volunteers
13 September 2022
Scientific Poster,
Translational Pharmaceutics, Clinical Pharmacology, Formulation Development
Assessment of the Contribution of CYP2D6 to the Elimination of Idalopirdine as well as the Absolute Bioavailability Following Multiple Oral Dosing
26 August 2022
Scientific Poster,
Translational Pharmaceutics, Clinical Trial Manufacturing, First-in-Human
Why Archiving is a Crucial Part of Any Clinical Trial
17 May 2022
Scientific Poster,
First-in-Human, Translational Pharmaceutics, Clinical Trial Manufacturing, Formulation Development
A First-in-Human (FIH) Study to Assess the Safety, Tolerability and Pharmacokinetics of Single and Multiple Doses, and Alternative Formulations of R941552 (R552): A selective Receptor Interacting Protein 1 (RIP1) Kinase Inhibitor
24 March 2022
Scientific Poster,
Modified Release, Formulation Development
Development of modified release matrix tablet formulation using solid lipid Compritol 888 for a poorly water soluble drug
22 December 2021
Scientific Poster,
Formulation Development
Influence of drug loading and fillers on drug release from HPMC matrix tablets
22 December 2021
Scientific Poster,
First-in-Human
An integrated radiolabelled study to determine the mass balance, metabolite profile and identification, and absolute bioavailability of nolasiban in healthy female subjects
22 December 2021
Scientific Poster,
Human ADME
ISSX NA 2021: An Integrated Radiolabelled Study to Determine the Mass Balance, Metabolite Profile and Identification and absolute bioavailability of Nolasiban in Healthy Female Subjects
17 September 2021
Scientific Poster,
Translational Pharmaceutics
Application of Translational Pharmaceutics® in Accelerating the Development of MR Dosage Forms
1 April 2021
Scientific Poster,
Clinical Pharmacology
Risk Based Monitoring from a Phase I Clinical Site Perspective
2 February 2021
Scientific Poster,
Spray Drying, Drug Product Optimization, Formulation Development
AAPS 2020 Poster: Improving the Stability of a Spray-Dried Peroxide-Susceptible Drug in Tablets
5 November 2020
Scientific Poster,
Formulation Development
AAPS 2020 Poster: Flexible formulation assessments in FIH studies for poorly soluble drugs accelerates dosage form development, manufacturing and supply for patient POC trials
5 November 2020
Scientific Poster,
Clinical Trial Manufacturing
AAPS 2020 Poster: Scale-up Challenge of a Low-Dose Tablet Formulation through Blending and Roller Compaction Optimization
5 November 2020
Scientific Poster,
Formulation Development
AAPS 2020 Poster: Development of High Drug Load Multiparticulate Beads Using an Extrusion-Spheronization Process
5 November 2020
Scientific Poster,
Formulation Development
AAPS 2020 Poster: A Quality by Design Approach to Optimize and Accelerate Formulation and Process Development Leading towards Registration Batches Manufacturing
5 November 2020
Scientific Poster,
Formulation Development
AAPS 2020 Poster: Development of Radiolabeled Surrogate Beads for Tracing Gastrointestinal Transit of Oral Multiparticulate Formulations
5 November 2020
Scientific Poster,
Pediatrics
EuPFI 2020 Poster: Current practice in the conduct of the acceptability - Palatability - swallowability trials - A review of methodology associated with trials registered on the EU clinical trials portfolio
20 July 2020
Scientific Poster,
Gamma Scintigraphy
CRS 2020 Poster: A Clinical Assessment of Delayed-Release Coated Capsule Compositions for Regional Gastrointestinal Delivery using Gamma Scintigraphy
29 June 2020
Scientific Poster,
Formulation Development
CRS 2020 Poster: Intestinal Transit and Release of Capsules with Different Coating Compositions Assessed by Gamma Scintigraphy in Healthy Subjects with Baseline Gastrointestinal pH, Temperature and Pressure Measured by SmartPill
29 June 2020
Scientific Poster,
Translational Pharmaceutics, Clinical Trial Manufacturing, First-in-Human, Formulation Development
Digital RDD 2020 Poster: Development of an X-ray Diffraction Method for the Quantification of API Recrystallized API
26 April 2020
Scientific Poster,
Translational Pharmaceutics, Human ADME, Spray Drying, First-in-Human, Modelling & Simulation
AAPS 2019 Poster: Comparison of Two In-Silico Modeling Programs, ADMET Predictor® and Percepta® to Predict Intrinsic Solubility and pKa of Poorly Soluble Drugs
4 November 2019
Scientific Poster,
Translational Pharmaceutics, Clinical Trial Manufacturing, Real-Time Manufacturing, Formulation Development, First-in-Human, Clinical Pharmacology
AAPS 2019 Poster: A Phase I Study Allowing Clinical Screening of Multiple Solubility-Enhancement Formulation Technologies, and an Assessment of Food, PPI and Dose Linearity Assessment with the Selected Formulation of BOS172767, in Healthy Volunteers
4 November 2019
Scientific Poster,
Spray Drying, Drug Product Optimization, Clinical Trial Manufacturing, First-in-Human
AAPS 2019 Poster: Development of a Solubilised Capsule Formulation Using Co-Micronization and Precipitation Inhibition
4 November 2019
Scientific Poster,
Oncology, Clinical Pharmacology
AAPS 2019 Poster: Applications and Benefits of Healthy Volunteer Trials to Accelerate Oncology Drug Development
4 November 2019
Scientific Poster,
Pediatrics
AAPS 2019 Poster: Clinical formulation development for poorly soluble 14C labelled molecules
4 November 2019
Scientific Poster,
Translational Pharmaceutics, Real-Time Manufacturing, First-in-Human
AAPS 2019 Poster: Rapid Transition of a Novel Celecoxib Formulation from a Fit-for-Phase Presentation to a Commercializable Product Using an Innovative Integrated Drug Development and Clinical Testing Platform
3 November 2019
Scientific Poster,
Pediatrics
EuPFI 2019 Poster: Development of Oral Liquid Products for Neonatal Patients
16 September 2019
Scientific Poster,
Pediatrics
EuPFI 2019 Poster: Development of a Paediatric Oral Suspension of a Novel Drug for the Treatment of Kidney Disease
10 September 2019
Scientific Poster,
Formulation Development
Developing spray dried dispersions for early phase clinical trials and beyond
1 May 2019
Scientific Poster,
Formulation Development, Clinical Pharmacology
ACAAI 2018 Poster: Phase 1/1b study of inhaled formulation in healthy volunteers & asthmatics
15 November 2018
Scientific Poster,
Translational Pharmaceutics, Clinical Trial Manufacturing, Formulation Development
AAPS 2018 Poster: Rapid Development and Clinical Assessment of New Rectal and Oral Formulations for Ulcerative Colitis Using Real-Time Adaptive GMP Manufacturing and Supply
5 November 2018
Scientific Poster,
Translational Pharmaceutics, Formulation Development
AAPS 2018 Poster: Identification and Optimization of Critical Process Parameters of Roller Compacted Capsules: From Development to Registration Batches
5 November 2018
Scientific Poster,
Pediatrics, Translational Pharmaceutics, Formulation Development
AAPS 2018 Poster: Development and Approval of a Palatable Glycopyrronium Bromide Liquid Formulation for Pediatrics
5 November 2018
Scientific Poster,
Formulation Development, Clinical Pharmacology
NACFC 2018 Poster: A pharmacokinetics and lung deposition study in healthy volunteers
18 October 2018
Scientific Poster,
Pediatrics
Creating Acceptable Tablets (CAT) -A feasibility study to assess the swallowability and acceptability of different sized placebo tablets in children and young people: an interim analysis
27 September 2018
Scientific Poster,
Modified Release, Formulation Development, Real-Time Manufacturing, Translational Pharmaceutics
CRS 2018 Poster: Development and Optimization of MR Formulations in the absence of predictive laboratory or preclinical models
23 July 2018
Scientific Poster,
Pediatrics, Clinical Pharmacology
ISSX 2018 Poster: Application Of Non Standard Approaches To Investigations Of Human Mass Balance And Metabolite Characterization
17 July 2018
Scientific Poster,
Drug Product Optimization
An Evaluation of the Pharmacodynamics, Safety, and Tolerability of the Potassium Binder RDX7675
30 May 2018
Scientific Poster,
Pediatrics, Clinical Trial Manufacturing, Formulation Development, Clinical Pharmacology, First-in-Human
Enhanced formulation decision-making in early phase clinical trials for parenteral products
17 January 2018
Scientific Poster,
Translational Pharmaceutics, Real-Time Manufacturing, Clinical Trial Manufacturing, Clinical Pharmacology, First-in-Human
AAPS 2017 Poster: Real-time drug product manufacturing to enable accelerated early clinical development of spray dried dispersion based formulations
22 November 2017
Scientific Poster,
Translational Pharmaceutics
AAPS 2017 Posters: On-stand presentations
22 November 2017
Scientific Poster,
Pediatrics
AAPS 2017 Poster: Enabling Clinical Assessment of Maralixibat for Rare Pediatric Liver Disease via Real Time Adaptive GMP Manufacturing
22 November 2017
Scientific Poster,
Modified Release, Clinical Pharmacology
AAPS 2017 Poster: Development of a Modified Release Tablet Containing an API Prone to Form Changes and Gelling in Aqueous Media
13 November 2017
Scientific Poster,
Formulation Development
AAPS 2017 Poster: Evaluation of Process Transferability of Poorly Flowing Blend Between the Blenders Manufactured by Different Vendors
13 November 2017
Scientific Poster,
Human ADME, Formulation Development, Clinical Pharmacology, First-in-Human
AAPS 2016 Poster: Formulation selection and development for ME-401 during a first-in-human study in healthy volunteers
7 November 2017
Scientific Poster,
Pediatrics
EuPFI 2017 Poster: A feasibility study to assess the acceptability of solid dosage forms in children
7 November 2017
Scientific Poster,
Human ADME, Clinical Pharmacology
ISSX 2017 Poster: Using 14C radiolabeled clinical studies to explore and evaluate factors influencing oral exposure
6 November 2017
Scientific Poster,
Regulatory Affairs, Clinical Pharmacology, First-in-Human
AAPS 2016 Poster: Comparisons between US and UK regulatory environments for conducting Phase I clinical research
6 November 2017
Scientific Poster,
Human ADME
ISSX 2017 Poster: Cocktail approach for assessing CYP450 drug-drug interaction liabilities
6 November 2017
Scientific Poster,
Human ADME
AAPS 2016 Poster: 14C Microtracer approaches to inform Formulation development strategies in Early Clinical Drug Development
6 November 2017
Scientific Poster,
Clinical Pharmacology
Intravenous studies in man: Teasing apart absorption and clearance drivers of pharmacokinetic variability and dose and time-dependent non-linearity
26 October 2017
Scientific Poster,
Human ADME, Oncology
AAPS 2015 Poster: Conduct of clinical ADME study for Vosaroxin in oncology patients
26 October 2017
Scientific Poster,
Human ADME, First-in-Human, Clinical Pharmacology
DMDG 2016 Poster: A Phase I, open-label, 2-Part study to establish absolute bioavailability
26 October 2017
Scientific Poster,
Drug Product Optimization
ADA 2017: Site of absorption of an oral formulation of semaglutide
26 October 2017
Scientific Poster,
Clinical Pharmacology, Formulation Development
APS 2012 Poster: Working with Short Shelf-Life Products in Clinical Development
26 October 2017
Scientific Poster,
Clinical Pharmacology, Clinical Trial Manufacturing, Real-Time Manufacturing, Oncology
AAPS 2014 Poster: Adaptive Manufacturing: A New Paradigm to Improve Efficiency and Effectiveness in Early Oncology Development
26 October 2017
Scientific Poster,
Translational Pharmaceutics, Clinical Trial Manufacturing, Clinical Pharmacology
ISSX 2016 Poster: Absorption, metabolism, and excretion of [14C]-gemigliptin
26 October 2017
Scientific Poster,
Human ADME, First-in-Human, Formulation Development
AAPS 2016: A Rapid Formulation Development and Clinical Testing Program to evaluate the Pharmacokinetics of a novel enabled formulation of Abiraterone Acetate
26 October 2017
Scientific Poster,
First-in-Human
AACR 2016 Poster: Clinical Pharmacokinetics and Pharmacodynamics of ME-401
26 October 2017
Scientific Poster,
Clinical Pharmacology
AAPS 2009 Poster: Intravenous and Oral Microdose Pharmacokinetics
26 October 2017
Scientific Poster,
Human ADME, Oncology
ISSX 2014 Poster: Flexible strategies for the conduct of human metabolism studies with oncology molecules
26 October 2017
Scientific Poster,
Spray Drying, Drug Product Optimization, Formulation Development
AAPS 2016 Poster: Maximizing the potential of amorphous spray-dried dispersions
26 October 2017
Scientific Poster,
Gamma Scintigraphy
APS 2013 Poster: Development of Novel Radiolabelling Method
26 October 2017
Scientific Poster,
Translational Pharmaceutics
RDD Poster: Application of Translational Pharmaceutics® to reduce time, cost and risk in the early development of inhaled drug products
26 October 2017
Scientific Poster,
Human ADME
AAPS 2016: A Rapid Formulation Development and Clinical Testing Program to evaluate the pharmacokinetics of a novel enabled formulation of Abiraterone acetate
26 October 2017
Scientific Poster,
Drug Product Optimization
ADA 2017: A pharmacoscintigraphic study of the relationship between tablet erosion and pharmacokinetics of oral semaglutide
26 October 2017
Scientific Poster,
Formulation Development, Clinical Pharmacology
AAPS 2015 Poster: Rapid Formulation Development and Clinical Testing of Gastro-Retentive Controlled Release Technology to Enable Once-Daily Dosing
26 October 2017
Scientific Poster,
Clinical Pharmacology
Biosimilars: A Transatlantic Drift?
26 October 2017
Scientific Poster,
Formulation Development
APS 2014 Poster: A rapid in vitro screen method for assessing the potential for precipitation of solubilized drugs in the small intestine
26 October 2017
Scientific Poster,
Translational Pharmaceutics
AAPS 2015: Real-time adaptive manufacturing - A new paradigm for personalized drug products in clinical development
26 October 2017
Scientific Poster,
First-in-Human
ASCPT 2016: A randomised double-blind dose escalation study to evaluate the safety and dose response of subcutaneous administration of coversin in healthy subjects
26 October 2017
Scientific Poster,
Formulation Development
AAPS 2009 Poster: Delivery of Antibodies to the Gastrointestinal Tract for Local Action
26 October 2017
Scientific Poster,
Pediatrics, Translational Pharmaceutics, Oncology
ISSX Poster: An Open-label, Two-period Study Designed to Evaluate and Compare the Mass Balance Recovery and Metabolite Profile of 14C-Deutetrabenazine and 14C-Tetrabenazine in Healthy Male Subjects
26 June 2017
Scientific Poster,
Pediatrics, Drug Product Optimization
EuPFI 2021: Taste Assessment Study of Belumosudil to Inform an Integrated Pediatric Formulation Development Program
Scientific Poster,
Clinical Pharmacology, First-in-Human
ASCPT 2021 Poster: A First in Human (FIH) Study to Assess the Safety, Tolerability and Pharmacokinetics of Single and Multiple Doses, and Alternative Formulations of R941552 (R552): A selective Receptor Interacting Protein 1 (RIP1) Kinase Inhibitor
Scientific Poster,
Bioanalysis
EBF 2021: Analysis of Ranitidine Reference Materials Using a Six N-Nitrosamine LC-MS/MS Assay
Scientific Poster,
Pediatrics, Formulation Development
EuPFI 2021: Development of a Novel Pediatric Belumosudil Oral Suspension
Scientific Poster,
Clinical Trial Manufacturing, Formulation Development, First-in-Human
How do I quickly develop first-in-human (FIH) dosage forms and avoid CMC delays whilst achieving proof-of-concept (POC)?
Scientific Poster,
Solubility Enhancement, Modified Release, Modelling & Simulation
AAPS 2021: Development and Application of a PBPK Model Using Theoretical Particle Size Distribution to Describe in vivo D issolution to Predict the Impact of Formulation Changes on Oral Bioavailability of GB001
Scientific Poster,
Pediatrics, Translational Pharmaceutics
Development of a Palatable Glycopyrronium Bromide Liquid for Paediatrics
Scientific Poster,
Bioanalysis
Analysis of Ranitidine Reference Materials Using a Six N-Nitrosamine LC-MS/MS Assay
Scientific Poster,
Modified Release
AAPS 2021: Pharmaceutical and clinical performance comparisons of modified release multiparticulates and matrix tablet formulations
Scientific Poster,
Clinical Pharmacology
HBI-3000: A Novel Drug for Conversion of Atrial Fibrillation - Phase 1 Study Results
Scientific Poster,
Bioanalysis
EBF 2021: Novel Copper Protein Speciation Method for Calculating Serum Non Ceruloplasmin Copper: A Comparative Analysis
Scientific Poster,
Formulation Development
Applications of Lipid-based Formulations and the Benefits of Integrating Manufacturing and Clinical Testing in Formulation Selection
Scientific Poster,
Modified Release
CRS 2021 Poster: Using formulation design spaces and clinical data to optimize development of modified release (MR) dosage forms
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